nordicICE Perfusion/DCE Module

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Dynamic image analysis is becoming increasingly important both in MRI and CT. For this purpose, two dedicated dynamic image analysis modules have been developed for nordicICE: a perfusion package and a permeability analysis package. With these two modules a large range of physiologically relevant parameters related to tissue perfusion and capillary permeability can be addressed both qualitatively and semi-quantitatively using state-of-the-art methods.

With the nordicICE Perfusion Module you can create high-quality perfusion maps from dynamic contrast enhanced MRI (T1 or T2/T2* weighted) or CT images in seconds. The combination of a user-friendly interface, state-of-the-art methods and very fast processing ensures maximum productivity without loss of quality. For the clinical workflow we provide a “one-button” perfusion analysis using pre-defined settings.

Perfusion Key features:

• State-of-the art deconvolution techniques: standard SVD or block-circulant SVD. Iterative or adaptive SVD threshold

• Fast generation of perfusion maps:
  • Blood volume (BV)
  • Blood flow (BF)
  • Mean Transit Time (MTT)
  • Time to Peak (TTP) or Delay (SVD)

• "One-button" perfusion analysis using pre-defined settings

• Choice of manual or fully automatic selection of arterial input function (AIF)

• Integrated motion correction

• Optimized for tumor perfusion analysis; including advanced processing methods like vessel segmentation and contrast agent leakage correction (”leakage” (Ktrans) maps)

• Visual (graphical) inspection of residue function and individual AIF pixels

• Large range of advanced processing options

• Optional gamma-variate fitting of input function and tissue curves

• Easy image fusion (drag & drop) of perfusion maps and structural images

nordicICE Dynamic Contrast Enhanced (DCE) Module has been developed for contrast agent permeability analysis based on a two-compartment tissue kinetic model. The DCE Module produces high-quality maps of several contrast agent permeability related parameters from dynamic contrast enhanced MRI or CT images using state-of-the-art methods. It is based on the same user-friendly interface as the nordicICE Perfusion Module ensuring easy transition between the two modules.

DCE Key features:

• State-of-the art deconvolution techniques for arterial input function (AIF) corrected kinetic analysis

• Fast generation of both quantitative maps:
  • Ktrans
  • kep
  • Distribution volume (Ve)
  • Plasma volume (Vp)
  and qualitative maps:
  • Area under curve (AUC)
  • Time to peak
  • Peak enhancement
  • Wash-in/wash-out rates

• Choice of manual or fully automatic selection of arterial input function (AIF) with visual inspection of individual AIF pixels

• Visual (graphical) inspection of selected arterial input function

• Integrated motion correction

• Large range of advanced processing options

• Easy image fusion (drag & drop) of perfusion maps and structural images

Image Courtsey of:

Division of Medical Imaging and Intervention, Rikshospitalet University Hospital, Oslo, Norway

Bob L. Hou, Memorial Sloan-Kettering Cancer Center, New York, USA and Central South University, Changsha, PRC

	Download nordicICE Tumor Perfusion Module Brochure (PDF 378KB)
	Play nordicICE Perfusion Tutorial